(1S,2R)-1-amino-2-methoxycyclohexane-1-carboxamide hydrochloride 0.25-hydrate

The title compound, (1-carboxamido-2-methoxycyclohexyl)ammonium chloride 0. 25-hydrate, C8H17N2O2+. Cl-. 0.25H(2)O, (I), was obtained in the course of our research efforts towards 2,4-propane analogues of the naturally occurri ng alpha-amino acid L-s-threonine. In order to elucidate the absolute stere ochemistry of (I), the absolute configuration was determined by exploiting anomalous dispersion effects. The crystal structure contains four independe nt molecules within the asymmetric unit, which are linked by a network of h ydrogen bonds and include the Cl- ions. The absolute configuration of all f our molecules is the same; however, differences in the conformation of some groups are present.