Anti-inflammatory and nitric oxide-inhibiting properties of granulocyte colony-stimulating factor

A proposed scheme between the possible interactions of pro- and anti-inflam matory cytokines, NO and G-CSF during severe inflammation/infection is pres ented. Taken together, these data indicate that G-CSF exhibits anti-inflamm atory properties which may prove to be beneficial in situations associated with an increased activity of the cellular immune system. Since the suppres sive effects of G-CSF on the production of pro-inflammatory mediators like TNF-alpha and nitric oxide are most likely neither cell type nor tissue spe cific, it is conceivable that NO release induced by pro-inflammatory mediat ors can be reduced by G-CSF in various organ systems and in different forms of shock. In this context, G-CSF might represent a counterregulatory mecha nism directed against downstream oriented inflammatory response to infectio n. Therefore, the investigation of G-CSF in the prophylaxis of nonneutropen ic infections, sepsis, and other severe inflammatory disorders seems reason able.