Idiopathic central retinal vein occlusion in a thrombophilic patient with the heterozygous 20210 G/A prothrombin genotype

PURPOSE: To report the occurrence of monolateral central retinal vein occlu sion in a patient with heterozygous 20210 G/A prothrombin genotype, known t o be associated with high thrombophilic risk. METHODS: A monolateral central retinal vein occlusion was diagnosed in a 71 -year-old woman, who had suffered from a deep vein thrombosis in her left l eg at the age of 36 years. Mutations of the genes involved in the coagulati on process were investigated by DNA polymerase chain reaction, RESULT: DNA analysis showed the patient to be heterozygous for the prothrom bin 20210 G/A genetic variation, CONCLUSION: The 20210 G/A prothrombin gene mutation may be associated with central retinal vein occlusion. (C) 1999 by Elsevier Science Inc. All right s reserved.