M. Halonen et al., Two subphenotypes of childhood asthma that differ in maternal and paternalinfluences on asthma risk, AM J R CRIT, 160(2), 1999, pp. 564-570
Asthma is a phenotypically heterogeneous disease. Two subgroups are defined
here based initially on skin test reactivity to the allergen Alternaria at
age 6 from among a large population of children born and raised in the Sou
thwestern desert environment of Tucson, Arizona. When compared with asthma
among Alternaria-positive subjects, asthma among Alternaria-negative subjec
ts was associated with lower levels of total serum IgE, no relation to loca
l aeroallergen skin tests, a younger age at diagnosis, greater remittance b
y age 11, and more frequent wheezing lower respiratory illnesses (LRIs) in
the first year of life. Despite the difference in total serum IgE, however,
IgE concentrations were significantly higher in each asthma group compared
with its respective control group. Asthma in each parent contributed appro
ximately equivalent risk for Alternaria-positive asthma in the child. Howev
er, neither parental skin test sensitization nor total serum IgE levels pro
vided risk for asthma in the child. Inheritance patterns for Alternaria-neg
ative asthma revealed a contribution from maternal but not paternal asthma.
Thus, dividing asthma in children at age 6 into Alternaria-positive and Al
ternaria-negative groups identifies subphenotypes that are further distingu
ished by differences in phenotypic markers and parental influences.