Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey

Authors
Plant, TM El Majdoubi, M Durrant, AR Sahu, A
Citation
Tm. Plant et al., Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey, ANN ENDOCR, 60(2), 1999, pp. 60-66
Citations number
43
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ANNALES D ENDOCRINOLOGIE
ISSN journal
00034266 → ACNP
Volume
60
Issue
2
Year of publication
1999
Pages
60 - 66
Database
ISI
SICI code
0003-4266(199907)60:2<60:DAOOTH>2.0.ZU;2-I
Abstract
The purpose of the present review is to describe, with particular emphasis on the rhesus monkey, the ontogeny and functional organisation of the hypot halamic GnRH pulse generator. Control of pituitary-gonadal axis in higher p rimates is provided by a group of some 1,000 GnRH neurons that are diffusel y distributed throughout the hypothalamus. After synthesis of a prehormone and formation of the mature decapeptide, GnRH is released in the hypophysia l portal circulation and stimulates FSH and LH production.