Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine

Hemolytic uremic syndrome (HUS) is a rare clinical and biological entity. H US has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens. Little information is avail able concerning the occurrence and outcome of this syndrome after administr ation of more recent chemotherapeutic agents. We present a case of HUS in a n advanced ovarian cancer patient treated with carboplatin end gemcitabine, and described its favorable outcome after chemotherapy interruption and su pportive care with a 1 year follow-up. [(C) 1999 Lippincott Williams & Wilk ins.].