Chemical structure and tumor type specificity of "half-mustard type" phenothiazines

The antiproliferative activity of sir "half-mustard type" phenothiazines ag ainst a total of 54 tumor cell lines: 4 leukemia, 9 non-small-cell lung, 7 colon; 5 CNS-, 8 melanoma, 6 ovarian; 8 renal; I prostate and 6 breast canc er was determined by NCI-Information Intensive-Approach. The C-2 position o f phenothiazines were substituted with H, CI and CF3-groups. The half-musta rd and ring system was linked either by a propylene or a butylene bridge. C olon-cancer cell showed the highest sensitivity against "half-mustard type" phenothiazines, followed by leukemia, melanoma, prostate-, CNS-, breast-, lung; renal and ovarian cancer cells. These data suggest the "cancer-type-s pecific" antitumor action of "half-mustard type" phenothiazines.