MYCOPHENOLATE MOFETIL AND PREDNISONE AS MAINTENANCE TREATMENT AFTER KIDNEY-TRANSPLANTATION

Background. Hemolytic uremic syndrome (HUS) is an infrequent but sever e complication of kidney transplantation. Cyclosporine-induced microan giopathy may be the causative factor in allograft recipients with HUS. In transplant recipients with HUS, discontinuation of cyclosporine is generally advised. This often leads to loss of the graft. Methods. An adult kidney transplant recipient developed HUS in the third week aft er transplantation. Maintenance immunosuppression was changed to mycop henolate mofetil and prednisone after cyclosporine was discontinued. R esults. The change in immunosuppressive therapy led to remission of th e HUS and stable graft function. Conclusions. In transplant recipients receiving cyclosporine who suffer from HUS, the possibility of conver sion from cyclosporine to mycophenolate mofetil should be considered. As this case shows, complete remission of HUS and maintenance of the g raft are possible.