9-deoxopodophyllotoxin derivatives as anti-cancer agents

Authors
Subrahmanyam, D Renuka, B Kumar, GS Vandana, V Deevi, DS
Citation
D. Subrahmanyam et al., 9-deoxopodophyllotoxin derivatives as anti-cancer agents, BIOORG MED, 9(15), 1999, pp. 2131-2134
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2131 - 2134
Database
ISI
SICI code
0960-894X(19990802)9:15<2131:9DAAA>2.0.ZU;2-X
Abstract
Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer acti vity was evaluated against <(in vitro)under bar> human cancer cell line ass ay. It was observed that these compounds do possess good anti-cancer activi ty particularly against ovarian, renal and lung cancer cell lines, (C) 1999 Elsevier Science Ltd. All rights reserved.