Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

Authors
Kolczewski, S Adam, G Stadler, H Mutel, V Wichmann, J Woltering, T
Citation
S. Kolczewski et al., Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists, BIOORG MED, 9(15), 1999, pp. 2173-2176
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2173 - 2176
Database
ISI
SICI code
0960-894X(19990802)9:15<2173:SOHEEA>2.0.ZU;2-R
Abstract
Heterocyclic enol ethers of type 1 were studied with respect to the inhibit ion of 1S,3R-ACPD (10 mu M)stimulated GTP gamma(35)S binding on rat mGluR2 transfected cell membranes. The structure activity relationship with regard to the substitution pattern of the phenyl ring, the oxygen substituent and the nature of the heterocycle is discussed, (C) 1999 Elsevier Science Ltd. All rights reserved.