Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

Authors
Groutas, WC Schechter, NM He, S Yu, HY Huang, P Tu, J
Citation
Wc. Groutas et al., Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold, BIOORG MED, 9(15), 1999, pp. 2199-2204
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2199 - 2204
Database
ISI
SICI code
0960-894X(19990802)9:15<2199:HCIBOT>2.0.ZU;2-3
Abstract
A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxi de scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase. (C) 1999 Elsevier Science Ltd. All rights r eserved.