7-amino-4-methyl-6-sulfocoumarin-3-acetic acid: A novel blue fluorescent dye for protein labeling

Authors
Leung, WY Trobridge, PA Haugland, RP Haugland, RP Mao, F
Citation
Wy. Leung et al., 7-amino-4-methyl-6-sulfocoumarin-3-acetic acid: A novel blue fluorescent dye for protein labeling, BIOORG MED, 9(15), 1999, pp. 2229-2232
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2229 - 2232
Database
ISI
SICI code
0960-894X(19990802)9:15<2229:7AANBF>2.0.ZU;2-T
Abstract
7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid (AMCA-S, also called Alexa(T M) 350) 2 was synthesized as a new water-soluble blue fluorescent dye for p rotein labeling. Compared with its nonsulfonated counterpart (AMCA) 1 the n ew dye gave significantly higher fluorescence quantum yields on proteins. ( C) 1999 Elsevier Science Ltd. All rights reserved.