Photonuclease activity of Taylor's blue

Authors
Mohammad, T Morrison, H
Citation
T. Mohammad et H. Morrison, Photonuclease activity of Taylor's blue, BIOORG MED, 9(15), 1999, pp. 2249-2254
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2249 - 2254
Database
ISI
SICI code
0960-894X(19990802)9:15<2249:PAOTB>2.0.ZU;2-7
Abstract
Taylor's blue (1,9-dimethylmethylene blue, DMMB+) associates with DNA, at l east in part, through intercalation as is evidenced from the red shift in t he absorption maximum, diminution of the fluorescence, and induced circular dichroism in the presence of nucleic acid. Irradiation of DMMB+/covalently closed circular supercoiled Phi X174 phage DNA complex at lambda > 520 nm leads to DNA nicking in a dose-dependent manner. (C) 1999 Elsevier Science Ltd. All rights reserved.