Rf. Kaltenbach et al., Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1 ' substituents, BIOORG MED, 9(15), 1999, pp. 2259-2262
A series of alkyl substituted P1/P1' analogs was prepared in an attempt to
increase translation of the 3-aminoindazole class of HIV protease inhibitor
s. Increasing the lipophilicity of the P1/P1' residues dramatically improve
d translation of enzyme activity to antiviral activity in the whole cell as
say. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.