Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1 ' substituents

Authors
Kaltenbach, RF Klabe, RM Cordova, BC Seitz, SP
Citation
Rf. Kaltenbach et al., Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1 ' substituents, BIOORG MED, 9(15), 1999, pp. 2259-2262
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2259 - 2262
Database
ISI
SICI code
0960-894X(19990802)9:15<2259:IAAOCU>2.0.ZU;2-Y
Abstract
A series of alkyl substituted P1/P1' analogs was prepared in an attempt to increase translation of the 3-aminoindazole class of HIV protease inhibitor s. Increasing the lipophilicity of the P1/P1' residues dramatically improve d translation of enzyme activity to antiviral activity in the whole cell as say. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.