Synthesis and biological evaluation of a new class of vaccine adjuvants: Aminoalkyl glucosaminide 4-phosphates (AGPs)

Authors
Johnson, DA Sowell, CG Johnson, CL Livesay, MT Keegan, DS Rhodes, MJ Ulrich, JT Ward, JR Cantrell, JL Brookshire, VG
Citation
Da. Johnson et al., Synthesis and biological evaluation of a new class of vaccine adjuvants: Aminoalkyl glucosaminide 4-phosphates (AGPs), BIOORG MED, 9(15), 1999, pp. 2273-2278
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
15
Year of publication
1999
Pages
2273 - 2278
Database
ISI
SICI code
0960-894X(19990802)9:15<2273:SABEOA>2.0.ZU;2-R
Abstract
A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-bet a-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesize d and screened for immunostimulant activity. Several of these compounds enh ance the production of tetanus toroid-specific antibodies in mice and augme nt vaccine-induced cytotoxic T cells against EG.7-ova target cells. (C) 199 9 Elsevier Science Ltd. Pill rights reserved.