Objective To compare lithogenic risk factors in normal black volunteer men
(BN), male black stone formers (BSF) and male white recurrent stone formers
(WSF); in addition, the differential diagnoses in the stone formers were c
ompared to determine if the causes of renal stones differed in the two grou
ps.
Subjects and methods The study included 22 BN, 22 consecutive BSF and 122 c
onsecutive WSF seen over a 10-year period. Each subject was assessed by a t
horough medical history, dietary analysis and a full serum and urinary bioc
hemical evaluation,
Results Although the WSF were significantly more overweight (P<0.001) and o
bese (P<0.001) than the BSF, neither group had values significantly differe
nt from those of their respective normal populations. There was no signific
ant difference in serum levels of Ca, phosphorus, ionised Ca, calcitriol an
d alkaline phosphatase in BSF and WSF, but levels of parathyroid hormone te
nded to be (P<0.1) and calcitriol was significantly higher in BSF than WSF
(P<0.03). The BSF urinary excretion levels tended to be more like that of t
he WSF, with the following pattern present; BN<BSF<WSF, except For citrate,
where BSF<BN<WSF. No dietary or metabolic abnormality was found in 9% of B
SF and 5% of WSF. Pure dietary lithogenic risk factors were present in 9% o
f BSF and 21% of WSF. The prevalence of metabolic risk factors was similar
in the two groups but the distribution differed. Renal hypercalciuria, abso
rptive hypercalciuria and mild metabolic hyperoxaluria were 2.5-3 times mor
e prevalent in the WSF,
Conclusion Although the urine of BSF tends to be more like that of WSF, the
lithogenic risk factors present differed and were less severe. The increas
e in urinary calcium excretion, coupled with a lower citrate excretion, may
be the most important reason for stone formation in the black population.
An increased protein intake may also play a role. In this small group of BS
F there was no family history of urolithiasis, supporting the view that the
re may be a more prominent genetic influence in WSF.