Injectable bone substitute using a hydrophilic polymer

We studied a new injectable biomaterial for bone and dental surgery consist ing of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP ceramics as fillers. This material is composed of complex fluids whose flo w is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube, The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomate rial, These flow properties are necessary to obtain Cap bioactivity in a de ntal canal or bone defect during percutaneous surgery. Macromolecules provi de spaces between CaP ceramic granules and facilitate the role of the biolo gical agents of bone substitution. (Bone 25:67S-70S; 1999) (C) 1999 by Else vier Science Inc. All rights reserved.