Cerebellar GABA(A) receptors and anxiolytic action of diazepam

Authors
Vekovischeva, OY Haapalinna, A Sarviharju, M Honkanen, A Korpi, ER
Citation
Oy. Vekovischeva et al., Cerebellar GABA(A) receptors and anxiolytic action of diazepam, BRAIN RES, 837(1-2), 1999, pp. 184-187
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
837
Issue
1-2
Year of publication
1999
Pages
184 - 187
Database
ISI
SICI code
0006-8993(19990807)837:1-2<184:CGRAAA>2.0.ZU;2-V
Abstract
Alcohol-sensitive ANT rats have a point mutation in the cerebellum-enriched GABA(A) receptor alpha 6 subunit, which makes this subunit and the ANT rat s in vivo highly sensitive to benzodiazepine agonists. In the elevated plus maze test of anxiety, diazepam produced a greater anxiolytic response in t he ANT rats than in the control, alcohol-insensitive AT rats. The ANT rats were less sensitive to the sedative effect of diazepam in the staircase tes t of exploration. The results thus suggest that the mutant cerebellar granu le cell layer receptors can participate in GABA(A) receptor-activation-indu ced anxiolysis. (C) 1999 Elsevier Science B.V. All rights reserved.