Hydroxylamine blocks pre- but not postsynaptic adenosine A(1) receptor-mediated actions in rat hippocampus

Authors
Fowler, JC Gervitz, L Partridge, LD
Citation
Jc. Fowler et al., Hydroxylamine blocks pre- but not postsynaptic adenosine A(1) receptor-mediated actions in rat hippocampus, BRAIN RES, 837(1-2), 1999, pp. 309-313
Citations number
28
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
837
Issue
1-2
Year of publication
1999
Pages
309 - 313
Database
ISI
SICI code
0006-8993(19990807)837:1-2<309:HBPBNP>2.0.ZU;2-#
Abstract
The commonly used nitric oxide donor, hydroxylamine (NH,OH), can block or r everse the inhibition of glutamatergic transmission by adenosine or an aden osine A, agonist in rat hippocampal slice. In these experiments, hydroxylam ine did not affect the adenosine A, receptor-mediated depression of postsyn aptic excitability. We conclude that hydroxylamine acts presynaptically to counter adenosine A, receptor-mediated inhibition of synaptic transmission. (C) 1999 Elsevier Science B.V. All rights reserved.