Recent reports have established oxidative stress and damage as playing a ro
le in the pathogenesis of a number of neurodegenerative diseases including
Alzheimer disease, Parkinson disease, corticobasal degeneration, Pick's dis
ease and Alexander's disease. Here we present evidence that oxidative damag
e is also one of the earliest cytopathological markers of neuronal dysfunct
ion in frontotemporal dementia.