Molecular genetic characterisation of frontotemporal dementia on chromosome 3

Authors
Ashworth, A Lloyd, S Brown, J Gydesen, S Sorensen, SA Brun, A Englund, E Humphreys, C Housman, D Badura, M Stanton, V Taylor, K Cameron, J Munroe, D Johansson, J Rossor, M Fisher, EMC Collinge, J
Citation
A. Ashworth et al., Molecular genetic characterisation of frontotemporal dementia on chromosome 3, DEMENT G C, 10, 1999, pp. 93-101
Citations number
40
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
ISSN journal
14208008 → ACNP
Volume
10
Year of publication
1999
Supplement
1
Pages
93 - 101
Database
ISI
SICI code
1420-8008(1999)10:<93:MGCOFD>2.0.ZU;2-7
Abstract
We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland ar ea of Denmark. Th is pedigree shows anticipation. Here we present further a nalysis of these anticipation data which are suggestive of trinucleotide re peat expansion involvement. We also outline our strategies to clone the mut ant gene via its putative associated trinucleotide repeat sequence.