This study's objective was to explore preclinical medical student's co
nsideration of psychosocial variables in problem-based learning (PBL)
cases. The authors used PBL cares that included psychosocial data and
case content focused on behavioral science, biological science, or a c
ombination of both. The authors compared, using one-way analysis of va
riance, the mean number of cues, learning issues, and hypotheses that
the students generated in their written responses to PBL cases that va
ried in the amount of psychosocial content. The results revealed that
the students identified psychosocial cues consistently across all curr
iculum segments, but the mean numbers of psychosocial hypotheses and l
earning issues were highest in the PBL case units dominated by psychos
ocial material. The authors conclude that the recognition of psychosoc
ial data as germane disease variables is achieved more easily than the
use of such data in a biopsychosocial formulation of traditional medi
cal problems. A lack of sophistication and experience might make the l
atter task difficult to accomplish for many second-year medical studen
ts without using specific educational strategies.