Acquired protein C deficiency following cisplatinum-navelbine administration for locally advanced breast cancer. Case report

Thromboembolic events have recently been reported following diverse regimen s of chemotherapy for breast cancer. This is a report of a 39-year-old woma n, a diagnosed case of locally advanced breast cancer, who received many re gimens of chemotherapy. She presented with deep venous thrombosis 2 months after starting the cisplatinum-navelbine regimen. Protein C deficiency was the only abnormal coagulation test that normalized after cessation of chemo therapy.