Villoglandular papillary adenocarcinoma of the uterine cervix

Villoglandular papillary adenocarcinoma of the uterine cervix was recently (1989) described by three main histological features: exophytic proliferati on, papillary architecture and mild to moderate cellular atypicality. The a uthors report a case of villoglandular papillary adenocarcinoma, clinical s tage IB, which was peculiar because of its association with a co-existing a nd simultaneously discovered invasive squamous cell carcinoma. These two pa tterns were juxtaposed and not intermingled. The patient was treated with r adical hysterectomy followed by vaginal radiation therapy. She remains with out evidence of recurrence after 12 months of follow-up. Five main clinicop athological features of the villoglandular papillary adenocarcinoma could b e stressed: rare histological variant (72 described cases), young age of pa tients (25-45 years old), superficial stromal invasion, usual association w ith other tumoral patterns (in situ or invasive adenocarcinoma as well as i n situ or invasive squamous cell carcinoma) and excellent prognosis. For se lected Cases, a conservative surgical approach (cervical conization) was po ssible. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.