Oligonucleotide-peptide conjugates as potential antisense agents

Oligonucleotide-peptide conjugates have several applications, including the ir potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling o f pre-synthesized peptides to the 2'-position of a selected nucleotide with in an otherwise protected oligonucleotide chain attached to a solid support . (C) 1999 Federation of European Biochemical Societies.