A novel K+ channel blocking toxin from Tityus discrepans scorpion venom

Authors
D'Suze, G Zamudio, F Gomez-Lagunas, F Possani, LD
Citation
G. D'Suze et al., A novel K+ channel blocking toxin from Tityus discrepans scorpion venom, FEBS LETTER, 456(1), 1999, pp. 146-148
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
456
Issue
1
Year of publication
1999
Pages
146 - 148
Database
ISI
SICI code
0014-5793(19990730)456:1<146:ANKCBT>2.0.ZU;2-7
Abstract
A novel toxin (TdK1) was purified from the venom of the scorpion Tityus dis crepans, sequenced and functionally characterized, It contains 37 amino aci d residues and blocks reversible the shakerB K+ channel expressed in SF9 ce lls with a K-d in the order of 280 nM, The proposed systematic nomenclature for this peptide is alpha-KTx4.3. (C) 1999 Federation of European Biochemi cal Societies.