Human reproductive failure is not a clinical feature associated with beta(2) glycoprotein-I antibodies in anticardiolipin and lupus anticoagulant seronegative patients (the antiphospholipid/cofactor syndrome)
J. Balasch et al., Human reproductive failure is not a clinical feature associated with beta(2) glycoprotein-I antibodies in anticardiolipin and lupus anticoagulant seronegative patients (the antiphospholipid/cofactor syndrome), HUM REPR, 14(8), 1999, pp. 1956-1959
It has been suggested that patients with clinical features suggestive of an
tiphospholipid syndrome but being lupus anticoagulant (LA) and anticardioli
pin (aCL) negative, should be tested for antibodies to beta(2) glycoprotein
-I (a beta(2)GP-I), a protein involved in the binding of antiphospholipid a
ntibodies (aPL) to phospholipid surfaces, This was investigated in the pres
ent study where a total of 385 women aged less than or equal to 40 years we
re included. Of these, 175 were experimental subjects and 210 were controls
, The former comprised the following two study groups: 100 spontaneous recu
rrent aborters (group one), and 75 patients with repeated failure of embryo
transfer (group two), Controls included three groups of women: 100 normal
healthy parous women with no previous abortion (group three), 60 infertile
patients achieving a live birth with their first in-vitro fertilization (IV
F)/embryo transfer attempt (group four), and 50 patients with recurrent abo
rtion who tested positive for aPL (LA and/or aCL) (positive controls, group
five). Only one patient among recurrent aborters (group one) tested positi
ve for a beta(2)GP-I, All women in groups two, three and four were negative
for a beta(2)GP-I screening. As expected, prevalence of patients testing p
ositive for a beta(2)GP-I was significantly higher in group five than among
the other groups of patients (P < 0.001). No differences were observed reg
arding the prevalence of a beta(2)GP-I positive sera in the subgroup of pat
ients having aCL and those having the LA in group five. It is concluded tha
t a beta(2)GP-I screening in first-trimester recurrent abortion or in failu
re of implantation after IVF is not warranted in patients without aPL as de
tected by standard antiphospholipid assays.