F. Goubel et al., CITRULLINE MALATE LIMITS INCREASE IN MUSCLE FATIGUE-INDUCED BY BACTERIAL-ENDOTOXINS, Canadian journal of physiology and pharmacology, 75(3), 1997, pp. 205-207
Citrulline malate is known to improve performance in weakened muscles.
The present experiment was designed to test the hypothesis that citru
lline malate can limit the effect of endotoxins on muscle fatigability
. Endotoxemia was induced in rats by injection of lipopolysaccharides
from Klebsiella pneumoniae. Resistance to fatigue was quantified by me
asuring tension production during repetitive electrical stimulation of
the isolated epitrochlearis muscle. Oral treatment by citrulline mala
te was found to increase resistance to fatigue in infected rats, where
as twitch tension was not modified. This demonstrates the efficacy of
citrulline malate for limiting an increase in muscle fatigue elicited
with bacterial endotoxins.