CITRULLINE MALATE LIMITS INCREASE IN MUSCLE FATIGUE-INDUCED BY BACTERIAL-ENDOTOXINS

Citrulline malate is known to improve performance in weakened muscles. The present experiment was designed to test the hypothesis that citru lline malate can limit the effect of endotoxins on muscle fatigability . Endotoxemia was induced in rats by injection of lipopolysaccharides from Klebsiella pneumoniae. Resistance to fatigue was quantified by me asuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. Oral treatment by citrulline mala te was found to increase resistance to fatigue in infected rats, where as twitch tension was not modified. This demonstrates the efficacy of citrulline malate for limiting an increase in muscle fatigue elicited with bacterial endotoxins.