Genomic alterations in human meningiomas detected by restriction landmark genomic scanning and immunohistochemical studies

Using restriction landmark genomic scanning (RLGS) methods, 21 samples of h uman meningioma were analyzed. We found 3 alterations in the genomic DNAs o f tumor samples located on chromosomes 5, 14 and 17 which appear to be comm on to the meningothelial subtype. Two other separate genetic abnormalities located on chromosomes 9-12 and 20 are apparently associated with atypical meningiomas. In addition, the neurofibromatosis type 2 gene is apparently i nvolved in more than half of the tumor samples. There appear to be both com mon and type-specific genetic mutations associated with the formation and p rogression of human meningiomas.