Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer

Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP524 11 (cell growth inhibitor) and transforming growth factor beta 1 (TGF beta 1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGF beta 1 treatment incr eased the level of apoptotic cells and CGP52411 treatment reduced EGF stimu lated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell reg ulation has a greater anti tumour action.