Quality of life in patients cured from a carcinoma of the head and neck byradiotherapy: The importance of the target volume

Purpose: To assess the health-related quality of life (QOL) of long-term su rvivors of carcinomas of different subsites of the head and neck following curative radiotherapy (RT), Patients and Methods: Patients continuously free from recurrence or second primary tumors treated 1988-1994 were contacted 5.1 to 5.9 years after RT a nd asked to fill in the EORTC QLQ-C30 core questionnaire and the H&N cancer module, RT had been restricted to the glottis (group A; carcinomas of the vocal cord T1-2 NO), or had included bilateral neck nodes and the primary t umor outside the nasophargnx (group B; AJC Stage II to IV) or within the na sopharynx, respectively (group C; Stage II to IV). Response rate was 97% (g roup ri; ii = 41), 69% (group B; n = 26) and 71% (group C; n 12), respectiv ely. The groups were different with respect to age (older in group A), alco hol consumption (absent in group C) and proportion of females (more in grou p C), Results: Patients with nasopharyngeal cancer reported the highest morbidity on the H&N module (dry mouth, sticky saliva, trismus. problems with teeth, trouble eating). However, these symptoms did not have a high impact on glo bal QOL or fuction scores on the QLQ-C30 core questionnaire, Patients in gr oup B reported a lower global QOL but less severe symptoms on the module. Conclusion: The high morbidity of patients treated for a nasopharyngeal can cer may be explained by the location of the target volume which included th e bilateral temporo-mandibular joints and the salivary glands. These patien ts require appropriate care during follow-up and will probably profit most from new RT techniques with sparing of normal tissues. (C) 1999 Elsevier Sc ience Inc.