Clinical remission of xeroderma pigmentosum-associated squamous cell carcinoma with isotretinoin and chemotherapy: Case report

We report the case of a 7-year old boy with xeroderma pigmentosum and a lar ge squamous cell carcinoma of the cheek. He received a combination of isotr etinoin (1 mg/kg/day) and chemotherapy for a period of 3 months and showed complete remission of the tumor. Treatment modalities of malignancies in xe roderma pigmentosum are reviewed and discussed in relation to the literatur e. The advantages of our protocol were emphasized because of the rapid impr ovement in a short time with minimal side effects.