Measurement of compliance with naltrexone in the treatment of alcohol dependence: Research and clinical implications

Citation
K. Namkoong et al., Measurement of compliance with naltrexone in the treatment of alcohol dependence: Research and clinical implications, J CLIN PSY, 60(7), 1999, pp. 449-453
Citations number
30
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
JOURNAL OF CLINICAL PSYCHIATRY
ISSN journal
01606689 → ACNP
Volume
60
Issue
7
Year of publication
1999
Pages
449 - 453
Database
ISI
SICI code
0160-6689(199907)60:7<449:MOCWNI>2.0.ZU;2-T
Abstract
Background: Medication compliance is a critical issue in pharmacotherapy. T his study evaluated the clinical utility of the Medication Event Monitoring System (MEMS), a newer method for monitoring medication compliance, compar ed with pill count, a traditional measure, in a sample of patients heated f or alcohol dependence with naltrexone. Method: Ninety-three outpatients meeting DSM-III-R criteria for alcohol dep endence participated in a 10-week open-label study of naltrexone. They were provided with naltrexone, 50 mg daily, and concurrent counseling. Measures of medication compliance and drinking during treatment were collected ever y 2 weeks. Results: Pill count yielded a significantly (p <.001) higher estimate of co mpliance (87.6% +/- 18.1%) than the MEMS (80.4% +/- 20.6%). However, the es timate of compliance obtained with the MEMS was more consistently correlate d with treatment outcome (percentage of days abstinent, percentage of heavy drinking days, and mean alcohol amount consumed per drinking occasion) tha n the pill count compliance rate. In addition, classification of the sample into compliant and less compliant groups using the:MEMS data yielded group s that differed more clearly on drinking outcomes than did stratification o n the basis of pill count. Conclusion: In pharmacotherapy research, the MEMS may provide more reliable and valid information about subjects' medication compliance than pill coun t. Clinically, information obtained with the MEMS could be used to provide feedback to patients about their pill-taking behavior to enhance compliance and overall outcome of therapy.