A. Paio et al., Solid-supported benzotriazoles: Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of amine libraries, J COMB CHEM, 1(4), 1999, pp. 317-325
This paper describes the successful transfer of benzotriazole-based chemist
ry on solid support. The strategy followed to anchor this peculiar heterocy
cle on solid phase and the full analytical characterization of the various
supported benzotriazoles are herein described. The chemistry assessment pro
cess on solid phase, the preparation of discrete libraries by parallel synt
hesis, the semiautomated purification procedures, and the complete analytic
al characterization of the library components are also presented and discus
sed.