Solid-supported benzotriazoles: Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of amine libraries

This paper describes the successful transfer of benzotriazole-based chemist ry on solid support. The strategy followed to anchor this peculiar heterocy cle on solid phase and the full analytical characterization of the various supported benzotriazoles are herein described. The chemistry assessment pro cess on solid phase, the preparation of discrete libraries by parallel synt hesis, the semiautomated purification procedures, and the complete analytic al characterization of the library components are also presented and discus sed.