Genetic engineering of doxorubicin production in Streptomyces peucetius: areview

Authors
Hutchinson, CR Colombo, AL
Citation
Cr. Hutchinson et Al. Colombo, Genetic engineering of doxorubicin production in Streptomyces peucetius: areview, J IND MIC B, 23(1), 1999, pp. 647-652
Citations number
38
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
13675435 → ACNP
Volume
23
Issue
1
Year of publication
1999
Pages
647 - 652
Database
ISI
SICI code
1367-5435(199907)23:1<647:GEODPI>2.0.ZU;2-8
Abstract
The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information c an be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.