Microcephaly, microphthalmia, congenital cataract, optic atrophy, short stature, hypotonia, severe psychomotor retardation, and cerebral malformations: a second family with micro syndrome or a new syndrome?

We report on four children of both sexes from a highly inbred family with h ypotonia, spastic diplegia, microcephaly, microphthalmia, congenital catara ct, optic atrophy, ptosis, kyphoscoliosis, short stature, severe mental ret ardation, and cerebral malformations. Six other children may also have been affected. The differential diagnosis and the possibility of a second famil y with the micro syndrome are discussed.