The aim of this study was to develop and validate a simple, quantifiable, n
eurologic examination for infants between 2 and 24 months of age. The asses
sment consists of 37 items, divided into 3 sections. The first section incl
udes 26 items assessing cranial nerve function, posture, movements, tone, a
nd reflexes; the second section of 8 items documents the development of mot
or function, and the third section of 3 items evaluates the state of behavi
or. We applied this assessment to a cohort of ninety-two 12-month-old infan
ts and forty-three 18-month-old infants, with no known perinatal risk facto
rs. The proforma presented has been designed according to the frequency dis
tribution of the neurologic findings in this cohort. Each item is scored in
dividually, and a global score is the sum of all individual scores. The qua
ntitative score enhances the value of this examination, both in clinical pr
actice and in research settings.