Scleromyxedema

Scleromyxedema is a sclerotic variant of papular mucinosis, in which lichen oid papules and scleroderma-like features are present. We describe a patien t with scleromyxedema with IgG type lambda chain paraprotein, a systemic sc lerosis-like illness, and myositis. The patient's serum contained Sd 70 ant ibodies, characteristic of scleroderma. Electromyography showed signs of ac ute myositis and the creatine phosphokinase (CPK) level was elevated. Multi ply passaged fibroblasts from the patient's skin lesions showed altered gro wth response in vitro. The patient was treated with cyclosporin (4 mg/kg/da y) with improvement.