Primary cutaneous marginal zone B-cell lymphoma: A report of 9 cases

Background: Primary cutaneous B-cell lymphoma is a heterogeneous group amon g which marginal zone B-cell lymphoma (MZL) appears to be the most common s ubtype. Objective: We analyze clinical presentation, histologic aspects, and outcom e of patients with primary cutaneous MZL. Methods: All samples classified as primary cutaneous lymphoma over the past 10 years were reviewed, and cases of primary MZL were identified. Results: Nine cases of MZL were analyzed, all from the upper body region, w ith a predominance in elderly women. Histologic aspects included a dense, n odular, deep-seated infiltrate containing various proportions of small cell s displaying a centrocyte-like, plasmacytoid or monocytoid appearance. Surf ace expression of CD5, CD10, and CD23 was negative. Long survival was noted but relapses in the skin, nodes, orbit, salivary glands, and breast were o bserved. Conclusion: MZL is the predominant primary cutaneous lymphoma of our study. It has distinctive histologic and clinical features as well as outcome.