We studied two cases of mobile internal carotid artery lesions in symptom-f
ree patients. Both cases were diagnosed by means of routine carotid duplex
ultrasound scanning, and neither patient was operated on. With medical ther
apy with oral anticoagulants, the two lesions spontaneously disappeared wit
hout any clinical sequel, and no evidence of infarcts was shown by means of
repeated computed tomography brain scans. After uneventful 2- and S-year f
ollow-up periods, there was no evidence of recurrence. This is the first pu
blished data on asymptomatic mobile carotid lesions and their natural histo
ry that shows a benign course in a long-term follow-up period. We suggest t
hat a nonsurgical approach may be considered selectively in high-risk sympt
om-free patients who have mobile and floating internal carotid artery lesio
ns.