Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2

Citation
Dr. Shafren et al., Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2, J VIROLOGY, 73(9), 1999, pp. 7193-7198
Citations number
46
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
9
Year of publication
1999
Pages
7193 - 7198
Database
ISI
SICI code
0022-538X(199909)73:9<7193:PRDBPA>2.0.ZU;2-J
Abstract
Therapeutic interference with virus-cell surface receptor interactions repr esents a viable antiviral strategy. Here we demonstrate that cytoplasmic ex pression of the serine protease inhibitor (serpin), plasminogen activator i nhibitor type 2 (PAI-2), affords a high level of protection from lytic infe ction by multiple human picornaviruses. The antiviral action of PAI 2 was m ediated primarily through transcriptional down-regulation of the following virus receptors: intercellular adhesion molecule 1 (ICAM-1, a cellular rece ptor for the major group of rhinoviruses), decay-accelerating factor (a cel lular receptor for echoviruses and coxsackieviruses), and to a lesser exten t the coxsackie-adenovirus receptor protein (a cellular receptor for group B coxsackieviruses and group C adenoviruses). Expression of related cell su rface receptors, including membrane cofactor protein and the poliovirus rec eptor, remained unaffected. These findings suggest that PAI-2 and/or relate d serpins may form the basis of novel antiviral strategies against picornav irus infections and also therapeutic interventions against ICAM-1-mediated respiratory inflammation.