Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Authors
Bergquam, EP Avery, N Shiigi, SM Axthelm, MK Wong, SW
Citation
Ep. Bergquam et al., Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo, J VIROLOGY, 73(9), 1999, pp. 7874-7876
Citations number
13
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
9
Year of publication
1999
Pages
7874 - 7876
Database
ISI
SICI code
0022-538X(199909)73:9<7874:RREALI>2.0.ZU;2-Y
Abstract
Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for t he presence of RRV by virus isolation and nested PCR The recovery and consi stent detection of RRV in the CD20(+)-enriched fraction clearly demonstrate s that B lymphocytes are a major site of virus persistence.