Coexistence of temporal lobe and idiopathic generalized epilepsies

Objective: To assess the interrelation of idiopathic generalized epilepsy ( IGE) and temporal lobe epilepsy (TLE) when they coexist in the same patient . Methods: The authors reviewed the electroclinical features of 350 consecu tive patients who had temporal resection between 1975 and 1997 at the Mauds ley and King's College Hospitals, London. Results: Two patients had the unu sual combination of TLE and IGE (0.57%). In the first, the clinical onset o f juvenile myoclonic epilepsy followed the surgical resolution of his parti al seizures but had been heralded for at least 5 years by subclinical spont aneous and photically induced generalized spike-wave discharges. In the sec ond, TLE and juvenile absence epilepsy had a long parallel course before su rgery. After surgery he had no further partial seizures. Conclusion: These cases suggest that when an idiopathic absence or myoclonic syndrome manifes ts in a patient with symptomatic TLE, the phenotype may not be a merged syn drome. Rather, the two conditions can retain their inherent electroclinical profile, responsiveness to treatment, and prognosis.