No association of alpha-2 macroglobulin gene five-nucleotide deletion withAD in Taiwan Chinese

Authors
Hu, CJ Sung, SM Liu, HC Lee, KY Hsu, WC Wong, WK Lee, CC Tsai, CH Chang, JG
Citation
Cj. Hu et al., No association of alpha-2 macroglobulin gene five-nucleotide deletion withAD in Taiwan Chinese, NEUROLOGY, 53(3), 1999, pp. 642-643
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
3
Year of publication
1999
Pages
642 - 643
Database
ISI
SICI code
0028-3878(19990811)53:3<642:NAOAMG>2.0.ZU;2-G
Abstract
The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M- 2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the a llele frequency of A2M-2 is lower than that found in the Caucasian populati on. Therefore, A2M-2 might not be a significant risk factor of AD among Tai wan Chinese.