Thymidine phosphorylase activity and angiogenesis in gastric cancer

Authors
Kakeji, Y Maehara, Y Tomoda, M Kabashima, A Oda, S Ooshiro, T Baba, H Kohnoe, S Sugimachi, K
Citation
Y. Kakeji et al., Thymidine phosphorylase activity and angiogenesis in gastric cancer, ONCOL REP, 6(5), 1999, pp. 995-999
Citations number
33
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021335X → ACNP
Volume
6
Issue
5
Year of publication
1999
Pages
995 - 999
Database
ISI
SICI code
1021-335X(199909/10)6:5<995:TPAAAI>2.0.ZU;2-I
Abstract
Angiogenesis has an important role in the growth and metastasis of solid tu mors. Several angiogenic factors have been identified, one being platelet-d erived endothelial cell growth factor (PD-ECGF), which is identical to thym idine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThd Pase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.