Clinical outcome in localized renal cell carcinomas related to immunoexpression of proliferating cell nuclear antigen, Ki-67 antigen, and tumor size

This study was designed to clarify the relationship between clinical outcom e and immunoexpression of proliferating cell nuclear antigen (PCNA) and Ki- 67 antigen (Ki-67) in 71 localized renal cell carcinomas (RCCs) of Robson s tage I and II, related to the disease recurrence and tumor size. PCNA and K i-67 expressions showed significant differences between non-recurring and r ecurring groups and more variability in stage II than in stage I; Recurrenc e rates according to tumor size were 0% for less than or equal to 2.5 cm, 4 % for 2.5 to 5.0 cm, and 55.8% for greater than or equal to 5.0 cm. It was concluded that PCNA and Ki-67 expression profiles were considered to be clo sely related to tumor stage and showed some promise for predicting the dise ase recurrence.