Re. Felgar et al., TIA-1 EXPRESSION IN LYMPHOID NEOPLASMS - IDENTIFICATION OF SUBSETS WITH CYTOTOXIC T-LYMPHOCYTE OR NATURAL-KILLER-CELL DIFFERENTIATION, The American journal of pathology, 150(6), 1997, pp. 1893-1900
TIA-1 is a 15-kd cytotoxic granule-associated protein expressed in nat
ural killer (NK) cells and cytotoxic T lymphocytes. TIA-1 expression w
as evaluated by paraffin immunohistochemistry in 115 T- or NK-cell neo
plasms, 45 g-cell neoplasms, and 45 Hodgkin's lymphomas. TIA-1-positiv
e granules were identified within the cytoplasm of neoplastic cells in
6/6 large granular lymphocytic leukemias, 11/11 hepatosplenic T-cell
lymphomas, 15/15 intestinal T-cell lymphomas, 6/6 NK-like T-cell lymph
omas of no special type, 2/2 NK-cell lymphomas, 8/9 nasal T/NK-cell ly
mphomas, 7/8 subcutaneous T-cell lymphomas, 4/5 pulmonary T- or NK-cel
l angiocentric lymphomas (lymphomatoid granulomatosis), 12/19 T-cell a
naplastic large-cell lymphomas, 2/12 nodal peripheral T-cell lymphomas
, 1/3 CD8(+) cutaneous T-cell lymphomas, and 5/38 classical Hodgkin's
disease, All B-cell neoplasms, nodular lymphocyte-predominant Hodgkin'
s disease (7 cases), CD4(+) cutaneous T-cell lymphomas (3 cases), adul
t T-cell leukemia/lymphomas (3 cases), T-cell chronic or prolymphocyti
c,tic leukemias (3 cases), and T-cell lymphoblastic leukemia/lymphomas
(7 cases) were TIA-1 negative. These findings indicate that most larg
e granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, inte
stinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas,
nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary an
giocentric lymphomas of T or NK phenotype, and anaplastic large-cell l
ymphomas are cytotoxic T- or NK-cell neoplasms.