TIA-1 EXPRESSION IN LYMPHOID NEOPLASMS - IDENTIFICATION OF SUBSETS WITH CYTOTOXIC T-LYMPHOCYTE OR NATURAL-KILLER-CELL DIFFERENTIATION

TIA-1 is a 15-kd cytotoxic granule-associated protein expressed in nat ural killer (NK) cells and cytotoxic T lymphocytes. TIA-1 expression w as evaluated by paraffin immunohistochemistry in 115 T- or NK-cell neo plasms, 45 g-cell neoplasms, and 45 Hodgkin's lymphomas. TIA-1-positiv e granules were identified within the cytoplasm of neoplastic cells in 6/6 large granular lymphocytic leukemias, 11/11 hepatosplenic T-cell lymphomas, 15/15 intestinal T-cell lymphomas, 6/6 NK-like T-cell lymph omas of no special type, 2/2 NK-cell lymphomas, 8/9 nasal T/NK-cell ly mphomas, 7/8 subcutaneous T-cell lymphomas, 4/5 pulmonary T- or NK-cel l angiocentric lymphomas (lymphomatoid granulomatosis), 12/19 T-cell a naplastic large-cell lymphomas, 2/12 nodal peripheral T-cell lymphomas , 1/3 CD8(+) cutaneous T-cell lymphomas, and 5/38 classical Hodgkin's disease, All B-cell neoplasms, nodular lymphocyte-predominant Hodgkin' s disease (7 cases), CD4(+) cutaneous T-cell lymphomas (3 cases), adul t T-cell leukemia/lymphomas (3 cases), T-cell chronic or prolymphocyti c,tic leukemias (3 cases), and T-cell lymphoblastic leukemia/lymphomas (7 cases) were TIA-1 negative. These findings indicate that most larg e granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, inte stinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary an giocentric lymphomas of T or NK phenotype, and anaplastic large-cell l ymphomas are cytotoxic T- or NK-cell neoplasms.