TC-99M TETROFOSMIN SCINTIGRAPHY TO EVALUATE BREAST-LESIONS

The aim of this study is to characterise benign from malignant breast lesions by using 99mTc-Tetrofosmin, Materials: Fifteen female patients with suspected breast lesions and ten normal controls underwent breas t scintigraphy with 99mTc-Tetrofosmin. All patients had conventional m ammography. Breast imaging begun 20 minutes after i.v. injection of 74 0 MBq 99mTc-Tetrofosmin. Patients were imaged in supine and prone posi tion. Results of the 15 patients with suspected breast lesions, 13 sho wed breast uptake, and 6 of them had suspicious lesions on mammography . Surgery confirmed 10 carcinomas and 3 benign lesions. Two patients d emonstrated no abnormal accumulation or suspicious findings in mammogr aphy. None of the normal controls had breast uptake or mammographic ab normalities. Our study has a sensibility of 100% and 60%, and a specif icity of 80% and 100% in scintigraphy and mammography respectively. Co nclusion: Our findings suggest that 99mTc-Tetrofosmin may play a role in evaluating breast masses and that can differentiate benign from mal ignant lesions.