TREATMENT OF METASTATIC BONE PAIN USING THE BONE SEEKING RADIOPHARMACEUTICAL RE-186-HEDP

Authors
DEKLERK JMH ZONNENBERG BA BLIJHAM GH SCHIP ADV HOEKSTRA A HAN SH QUIRIJNEN JMSP VANDIJK A VANRIJK PP
Citation
Jmh. Deklerk et al., TREATMENT OF METASTATIC BONE PAIN USING THE BONE SEEKING RADIOPHARMACEUTICAL RE-186-HEDP, Anticancer research, 17(3B), 1997, pp. 1773-1777
Citations number
21
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
17
Issue
3B
Year of publication
1997
Pages
1773 - 1777
Database
ISI
SICI code
0250-7005(1997)17:3B<1773:TOMBPU>2.0.ZU;2-O
Abstract
Recent advances in radionuclide therapy offer a new approach for the m anagement of metastatic bone pain. This paper reports the results of d osage escalation studies with Re-186-HEDP as a bone-seeking radiopharm aceutical in patients with bone metastases originating from breast or prostate cancer with regard to toxicity, pharmacokinetics and bone mar row dosimetry and the palliating effect on bone pain. Thrombocytopenia proved to be the dose limiting factor and Re-186-HEDP showed a consid erable efficacy in end-stage patients with metastatic bone pain''.