S. Abbas et Cj. Hayes, A novel palladium-catalysed coupling strategy for the rapid synthesis of nucleic acid analogues bearing modified backbones, SYNLETT, (7), 1999, pp. 1124-1126
The synthesis of a 5'-deoxy-5'-methylidene phosphonate-containing thymidine
dimer 14 has been achieved using a palladium-catalysed cross coupling reac
tion as a key step. The E-vinyl bromide 9 was synthesised from the correspo
nding 1,1-dibromoolefin 7 via selective reduction using dimethylphosphite a
nd triethylamine.